Related Experiment Video
Updated: Aug 2, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
Production and regulation of tumor necrosis factor alpha. A cellular and molecular analysis
S L Kunkel1, M Spengler, G Kwon
1Department of Pathology, University of Michigan Medical School, Ann Arbor.
Abstract:
Tumor necrosis factor alpha is increasingly being recognized as an important macrophage-derived cytokine that possesses pleomorphic effects in both physiologic and immunologic systems. Current evidence has demonstrated that tumor necrosis factor may stimulate a plethora of cellular responses in vitro and induce multiple physiologic derangements when given in vivo. While the biologic activity of tumor necrosis factor elaborated by macrophages and macrophage cell lines in response to bacterial and protozoal cell products have been well documented, the endogenous factors that regulate the production of this monokine are not as clearly delineated. This chapter focuses on the cellular and molecular mechanisms that endogenously regulate the production of tumor necrosis factor.
More Related Videos
08:19Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
06:16Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
Published on: December 7, 2019
Related Concept Videos
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
The Tumor Microenvironment
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Regulation of Angiogenesis and Blood Supply
TGF - β Signaling Pathway