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Spatial and functional heterogeneity of follicular helper T cells in autoimmunity

Abhinav Seth1, Joe Craft2

  • 1Department of Internal Medicine, Section of Rheumatology, New Haven, CT, United States.

Current Opinion in Immunology
|August 3, 2019
PubMed

Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicular spaces - either in secondary lymphoid or non-lymphoid tissues. Both follicular and extrafollicular T helper cells drive autoantibody-mediated autoimmunity. Interfering with B cell help provided by T cells can ameliorate autoimmune disease in animal models and human patients. The next frontier in Tfh cell biology will be identification of Tfh cell-specific pathogenic changes in autoimmunity and exploiting them for therapeutic purposes.

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