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Updated: Jan 21, 2026

Rat Model of Normothermic Ex-Situ Perfused Heterotopic Heart Transplantation
Published on: April 21, 2023
Discrepancies in access and institutional risk tolerance in heart transplantation: A national open cohort study
Alejandro Suarez-Pierre1, Cecillia Lui1, Xun Zhou1
1Department of Surgery, Division of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Insights
Sociodemographic factors like age, education, and insurance influence access to high-volume heart transplant centers. These centers offer better survival, highlighting the need to improve access for underserved populations.
Area of Science:
- Cardiology
- Transplant Surgery
- Health Services Research
Background:
- Center volume is a recognized benchmark in heart transplantation for certification and reimbursement.
- Understanding factors influencing access to high-volume centers is crucial for equitable care.
Purpose of the Study:
- To investigate sociodemographic variables associated with accessing high-volume heart transplant centers.
- To emphasize the importance of expanding access to these specialized centers for underserved patient groups.
Main Methods:
- Analysis of adult heart transplant data from 2006-2015, involving 18,725 patients across 145 centers.
- Centers categorized into terciles based on annual transplant volume (<14, 14-25, >25 transplants).
- Multinomial regression used to identify factors associated with receiving care at different volume centers.
Main Results:
- Younger age, lower education, and government insurance were linked to lower odds of care at high-volume centers.
- High-volume centers managed higher-risk recipients and accepted organs from higher-risk donors.
- Care at high- and intermediate-volume centers correlated with improved 1-year survival compared to low-volume centers.
Conclusions:
- Access to high- and intermediate-volume heart transplant centers is influenced by social, demographic, and geographic factors.
- High-volume centers demonstrate capacity to manage increased risk while achieving excellent patient survival outcomes.
- Increased awareness of these access disparities should drive efforts to extend care to underserved populations.
Background:
The impact of center volume on heart transplantation is widely recognized and serves as a benchmark for certification and reimbursement.
Study Aims:
Study sociodemographic variables associated with access to high-volume centers and substantiate the importance of extending access to underserved populations.
Methods:
This study focused on adults undergoing heart transplantation between 2006 and 2015. Centers were clustered into terciles (>25, 14-25, or <14 transplants per year) and factors associated with receiving care in different terciles were identified through multinomial regression.
Results:
During the study period, 18 725 patients were transplanted at 145 centers. Younger age (<30 years) (P = .005), lower educational level (P < .001), and government-based insurance (P < .001) were associated to lower odds of receiving care at a high-volume center. These centers had higher risk recipients and accepted organs from higher risk donors, when compared to intermediate- and low-volume centers. Receiving care at high (odds ratio [OR], 1.212; P = .017) and intermediate-volume centers (OR, 1.304; P = .001) was associated with greater odds of 1-year survival when compared with low-volume centers.
Conclusion:
Social, demographic, and geographic factors affect access to high- and intermediate-volume centers. High-volume centers tolerate more risk while providing excellent survival. Awareness of this impact should prompt an extension of access to care for underserved patient populations.
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