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Increased risk of atopic diseases in boys with meatal stenosis: a possible pathophysiological relation

Behnam Nabavizadeh1, Parya Akbari1, Seyedeh Sanam Ladi Seyedian1

  • 1Pediatric Urology and Regenerative Medicine Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Pediatric Surgery
|August 4, 2019
PubMed
Abstract

Insights

Boys with meatal stenosis are significantly more likely to have a history of atopy, including conditions like eczema and asthma. This suggests a link between allergic reactions and the development of meatal stenosis in children.

Area of Science:

  • Pediatric Urology
  • Allergology
  • Dermatology

Background:

  • Meatal stenosis, a narrowing of the urethral opening, affects pediatric patients.
  • The exact causes of meatal stenosis are not fully understood.
  • Atopy, encompassing conditions like atopic dermatitis, allergic rhinitis, asthma, and food allergies, is a common condition in children.

Purpose of the Study:

  • To investigate the potential association between atopy and the development of meatal stenosis in boys.
  • To evaluate if allergic conditions contribute to the pathophysiology of meatal stenosis.

Main Methods:

  • A retrospective case-control study was conducted.
  • Records of boys diagnosed with meatal stenosis (Group A) and a control group (Group B) were reviewed.
  • History of atopic conditions was compared between the two groups.

Main Results:

  • A significantly higher proportion of boys with meatal stenosis (61.16%) had a history of allergic reactions compared to the control group (13.12%).
  • The likelihood of suffering from allergic reactions was significantly higher in patients with meatal stenosis (P < 0.001).

Conclusions:

  • This study indicates a significant relationship between hypersensitivity reactions (atopy) and meatal stenosis in boys.
  • Persistent inflammation associated with atopy may play a role in the scarring and subsequent stenosis of the meatus.
  • Further research is needed to fully elucidate the underlying pathophysiology.
Keywords:
AllergyAtopyCircumcisionMeatal stenosis

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