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Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

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The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
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Related Experiment Video

Updated: Jan 21, 2026

Aseptic Laboratory Techniques: Plating Methods
18:00

Aseptic Laboratory Techniques: Plating Methods

Published on: May 11, 2012

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Aseptic meningitis.

P Tattevin1, S Tchamgoué2, A Belem1

  • 1Service de maladies infectieuses et réanimation médicale, CHU de Pontchaillou, rue Le Guilloux, 35033 Rennes Cedex, France.

Revue Neurologique
|August 4, 2019
PubMed
Summary
This summary is machine-generated.

Aseptic meningitis involves inflammation of the meninges without infection. Causes include systemic diseases, drugs, and cancer, but many cases remain idiopathic.

Keywords:
Aseptic meningitisBehçet diseaseDrug-induced aseptic meningitisNeoplastic meningitisSarcoidosis

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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
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Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Aseptic meningitis is defined by meningeal inflammation (CSF pleocytosis ≥5 cells/mm³) not caused by infection.
  • Etiologies encompass systemic diseases (sarcoidosis, lupus), drug-induced reactions (NSAIDs, antibiotics), and neoplastic meningitis (cancers, lymphomas).
  • Distinguishing aseptic meningitis from infectious causes and parameningeal infections is crucial for diagnosis.

Purpose of the Study:

  • To review the main causes and characteristics of aseptic meningitis.
  • To highlight the challenges in diagnosing aseptic meningitis, including differentiating it from infectious etiologies.
  • To discuss the proportion of idiopathic cases and the impact of newly identified syndromes like HaNDL.

Main Methods:

  • Literature review of aseptic meningitis etiologies.
  • Classification of causes into systemic diseases, drug-induced, and neoplastic categories.
  • Discussion of differential diagnoses, including infectious meningitis and parameningeal infections.

Main Results:

  • Systemic diseases, drugs, and neoplasms are primary causes of aseptic meningitis.
  • A significant proportion, up to two-thirds, of aseptic meningitis cases are labeled idiopathic.
  • Advances in diagnostics like PCR and NGS aid in identifying causes, yet many remain unknown.

Conclusions:

  • Aseptic meningitis has diverse etiologies requiring careful differential diagnosis.
  • Many cases remain idiopathic despite diagnostic advancements, underscoring the need for further research.
  • Recognition of specific syndromes may reduce the 'idiopathic' classification rate.