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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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RNA Splicing01:32

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Nursing Code of Ethics01:29

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The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
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Transfer RNA Synthesis02:36

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One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
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Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
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Research Progress on Long Non-Coding RNA and Radiotherapy.

Zhifeng Yao1,2, Yiwen Zhang3, Danghui Xu4

  • 1Department of Radiotherapy, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
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Long non-coding RNAs (lncRNAs) are crucial in cancer development and progression. This review explores their role in radiotherapy, impacting tumor cell radiation sensitivity across various cancers.

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Related Experiment Videos

Last Updated: Jan 21, 2026

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators in biological and pathological processes.
  • Abnormal lncRNA expression is implicated in various human cancers, acting as oncogenes or tumor suppressors.
  • lncRNAs are increasingly recognized for their role in cancer progression and response to therapy.

Purpose of the Study:

  • To review the biological functions and mechanisms of lncRNAs in human cancers undergoing radiotherapy.
  • To explore how lncRNAs influence cancer progression and radiation sensitivity.
  • To consolidate current research on lncRNAs in radiotherapy for specific cancers.

Main Methods:

  • Literature review of published studies on lncRNAs and radiotherapy.
  • Analysis of lncRNA expression patterns in cancer cells.
  • Investigation of lncRNA-mediated signaling pathways and cell cycle regulation.

Main Results:

  • lncRNAs are involved in proliferation, apoptosis, migration, invasion, angiogenesis, and immune escape in cancers.
  • Abnormal lncRNA expression affects cancer progression and radiation sensitivity.
  • Specific lncRNAs mediate effects through signaling pathways and cell cycle regulation.

Conclusions:

  • lncRNAs play a significant role in the biological functions and mechanisms of human cancers.
  • Understanding lncRNA roles in radiotherapy is crucial for improving cancer treatment outcomes.
  • Further research into lncRNAs in radiotherapy is warranted for esophageal, pancreatic, nasopharyngeal, hepatocellular, cervical, colorectal, and gastric cancers.