Related Experiment Video

Updated: Jan 21, 2026

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1

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Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML

Thomas Oellerich1,2,3, Constanze Schneider1,3,4, Dominique Thomas5

  • 1Department of Medicine II, Hematology/Oncology, Goethe University of Frankfurt, Frankfurt, 60590, Germany.

Nature Communications
|August 4, 2019
PubMed

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