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Pharmacotherapy in Pediatric Hematopoietic Cell Transplantation

R Admiraal1, J J Boelens2,3

  • 1Blood and Marrow Transplantation Program, Prinses Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Handbook of Experimental Pharmacology
|August 4, 2019
PubMed

Insights

Individualized dosing in hematopoietic cell transplantation (HCT) can improve drug safety and efficacy. This approach may lead to better immune reconstitution, disease control, and survival outcomes for patients undergoing HCT.

Area of Science:

  • Hematology
  • Pharmacology
  • Oncology

Background:

  • Hematopoietic cell transplantation (HCT) offers curative potential for various diseases.
  • Treatment success hinges on disease control and managing complications.
  • Pharmacotherapy is integral to HCT, influencing outcomes through conditioning, GvHD prophylaxis, and infection management.

Purpose of the Study:

  • To explore the impact of individualized dosing strategies in pediatric hematopoietic cell transplantation.
  • To determine if personalized pharmacotherapy enhances treatment predictability, safety, and efficacy.
  • To assess the potential of individualized dosing for improving immune reconstitution, disease control, and survival rates.

Main Methods:

  • Review of current pharmacotherapy practices in HCT.
  • Analysis of emerging evidence supporting dose individualization in pediatric HCT.
  • Evaluation of safety and efficacy parameters associated with tailored drug regimens.

Main Results:

  • Individualized dosing shows promise for optimizing drug treatment in HCT.
  • Personalized approaches may lead to more predictable safety and efficacy profiles.
  • Evidence suggests improved immune reconstitution and disease control with tailored dosing.

Conclusions:

  • Individualized dosing in HCT can enhance patient outcomes.
  • Personalized pharmacotherapy is crucial for achieving timely immune reconstitution and optimal disease control.
  • Tailored drug regimens hold the potential to improve survival chances in HCT patients.

Keywords:
Cellular therapiesConditioningGraft-versus-host diseaseHematopoietic cell transplantationIndividualized dosingRelapseTherapeutic drug monitoring

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