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Liver to Pancreas Transdifferentiation

Irit Meivar-Levy1,2, Sarah Ferber3,4,5

  • 1The Sheba Regenerative Medicine, Stem Cell and Tissue Engineering Center, Sheba Medical Center, 56261, Tel-Hashomer, Israel.

Current Diabetes Reports
|August 4, 2019
PubMed
Summary

Generating insulin-producing cells from liver cells via transdifferentiation (TD) shows promise for diabetes treatment. Enhancing TD efficiency and cell maturation are key for clinical application in autologous cell replacement therapy.

Keywords:
3D culture (three-dimensional spheroids)Autologous insulin-producing cells (AIP cells)DiabetesEpigenetic modificationsLiverPancreatic transcription factors (pTFs)ReprogrammingTransdifferentiation (TD)Wnt signaling

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