Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Factors affecting serotonin uptake into human platelets.

E E Codd1, T W McAllister, R F Walker

  • 1Department of Reproductive and Developmental Toxicology, Smith Kline and French Laboratories, King of Prussia, PA 19406-0939.

Psychopharmacology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex Differences Across Concussion Characteristics in US Service Academy Cadets: A CARE Consortium Study.

Sports medicine (Auckland, N.Z.)·2024
Same author

Baseline concussion assessment performance by sex in military service academy rugby players: findings from the CARE Consortium.

BMJ military health·2023
Same author

Vapor Pressures of Platinum, Iridium, and Rhodium.

Journal of research of the National Bureau of Standards. Section A, Physics and chemistry·2020
Same author

Vapor Pressures of Ruthenium and Osmium.

Journal of research of the National Bureau of Standards. Section A, Physics and chemistry·2019
Same author

Impact of anticoagulant choice on hospitalized bleeding risk when treating cancer-associated venous thromboembolism.

Journal of thrombosis and haemostasis : JTH·2018
Same author

On the Cause and Mechanism of Phenoptosis.

Biochemistry. Biokhimiia·2018
Same journal

Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice.

Psychopharmacology·2026
Same journal

Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<sub>1</sub> and 5-HT<sub>1A</sub> receptor signaling.

Psychopharmacology·2026
Same journal

Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.

Psychopharmacology·2026
Same journal

Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study.

Psychopharmacology·2026
Same journal

Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.

Psychopharmacology·2026
Same journal

OPRD1 rs4654327 and Outcomes of Extended-Release Naltrexone in Alcohol Use Disorder: An Exploratory Prospective Pharmacogenetic Study.

Psychopharmacology·2026
See all related articles

Platelet serotonin uptake shows significant variability. A new measure, "total Vmax," accounts for platelet count, reducing data scatter and revealing age-related declines in serotonin transport capacity.

Area of Science:

  • Pharmacology
  • Biochemistry
  • Chronobiology

Background:

  • Platelet serotonin uptake is complex and influenced by various factors.
  • Standard Vmax measurements (per cell) show high inter-individual and temporal variability.
  • Understanding factors affecting serotonin transport is crucial for neurological research.

Purpose of the Study:

  • To investigate the influence of time of day, season, and age on platelet serotonin uptake parameters.
  • To identify a more robust and physiologically relevant measure of Vmax.
  • To assess age-related changes in platelet serotonin transport.

Main Methods:

  • Kinetic analysis of 5-hydroxytryptamine (5-HT) uptake in human platelets.
  • Comparison of Vmax (moles/cell number/time) and a novel 'total Vmax' (moles/time) metric.

Related Experiment Videos

  • Analysis of data across different times of day, seasons, and age groups.

    • Main Results:

    • Standard Vmax exhibited significant variability between individuals and over time.
    • An inverse relationship was observed between Vmax and platelet count.
    • Total Vmax significantly reduced data scatter and showed a statistically significant decline with increasing subject age.

    Conclusions:

    • Total Vmax, normalized to the total platelet count in plasma, is a more reliable and physiologically relevant measure of platelet serotonin uptake.
    • Age significantly impacts total Vmax, suggesting age-related alterations in serotonin transport regulation.
    • This revised metric offers improved insights into serotonin dynamics and its age-dependent changes.