Clinical Utility of [18F]FDG-PET /CT in Pericardial Disease

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Min-Sun Kim1, Eun-Kyung Kim1, Joon Young Choi2

  • 1Division of Cardiology, Department of Medicine, Samsung Medical Center, Heart Vascular and Stroke Institute Imaging Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.

Current Cardiology Reports
|August 4, 2019
PubMed

Insights

Diagnosing pericardial disease is difficult, but [18F]FDG-PET/CT imaging can help. This technique visualizes inflammation and malignancy, aiding in treatment planning and prognosis for pericardial conditions.

Area of Science:

  • Nuclear Medicine
  • Cardiology
  • Oncology

Background:

  • Pericardial disease diagnosis is challenging due to limited access to pericardial fluid and tissue.
  • Pericardial disease can be an early sign of systemic diseases, necessitating accurate etiological identification.
  • Early detection and management of pericarditis are crucial to prevent long-term complications.

Purpose of the Study:

  • To review the clinical utility of [18F]-2-deoxy-2-fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) for diagnosing and managing pericardial disease.
  • To assess the role of [18F]FDG-PET/CT in differentiating between inflammatory and neoplastic causes of pericardial disease.
  • To evaluate the potential of [18F]FDG-PET/CT in guiding anti-inflammatory treatment strategies.

Main Methods:

  • Review of existing literature on [18F]FDG-PET/CT applications in pericardial disease.
  • Analysis of [18F]FDG-PET/CT imaging characteristics in various pericardial conditions.
  • Correlation of imaging findings with clinical outcomes and treatment responses.

Main Results:

  • [18F]FDG-PET/CT effectively visualizes hypermetabolic activity in the pericardium, indicative of inflammation or malignancy.
  • The pattern of [18F]FDG uptake can help distinguish neoplastic from inflammatory etiologies.
  • High pericardial [18F]FDG uptake, after excluding malignancy, suggests active inflammation and predicts response to anti-inflammatory therapy.

Conclusions:

  • [18F]FDG-PET/CT is a valuable tool for the diagnosis of pericardial disease, offering insights into etiology.
  • The imaging modality aids in establishing prognosis and planning targeted anti-inflammatory treatments.
  • [18F]FDG-PET/CT can potentially improve patient outcomes by enabling precise management of pericardial conditions.

Keywords:
Constrictive pericarditisPericardial diseasePericarditisPositron emission tomography

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