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Antidepressant effect of 5-methoxypsoralen: a preliminary report
E Souêtre1, E Salvati, J L Belugou
1Clinique de Psychiatrie et de Psychologie Medicale, Hôpital Pasteur, Nice, France.
Psychopharmacology
|January 1, 1988
Abstract:
5-Methoxypsoralen (5 MOP) administered daily (40 mg at 9 p.m.) was compared with placebo in the treatment of severe depression. The clinical response was evaluated using the Hamilton Depression Rating Scale after 1 week of treatment. Our preliminary data indicate that patients receiving 5 MOP improved significantly after 1 week, whereas patients treated with placebo did not. The stimulating effect of 5 MOP on the melatonin secretion may be involved in this clinical effect.