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Allergic Reactions

Allergic Reactions

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

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Updated: Jan 21, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

ORMDL3 and allergic asthma: From physiology to pathology.

Briana James¹, Sheldon Milstien¹, Sarah Spiegel¹

¹Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Va.

The Journal of Allergy and Clinical Immunology

|August 4, 2019

Summary

The ORMDL3 gene plays a key role in allergic asthma pathogenesis by regulating sphingolipid homeostasis. Understanding its function may lead to new biomarkers for asthma.

Keywords:

Asthma ORM1 (yeast)–like protein 3 ceramide endoplasmic reticulum stress sphingolipids unfolded protein response

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Area of Science:

Immunology
Genetics
Biochemistry

Background:

Asthma has a strong genetic component, with ORMDL3 identified as a key susceptibility gene.
The precise role of ORMDL3 in asthma pathogenesis and its physiological functions remain debated.
Recent research focuses on elucidating the multifaceted functions of ORMDL3 in allergic asthma.

Purpose of the Study:

To describe recent advances in understanding ORMDL3's functions in allergic asthma.
To propose a unifying paradigm for ORMDL3's pathological roles.
To explore the link between ORMDL3, sphingolipid homeostasis, and asthma.

Main Methods:

Review of recent scientific literature on ORMDL3 and asthma.
Analysis of molecular mechanisms underlying ORMDL3's function in sphingolipid metabolism.
Survey of sphingolipid metabolites as potential asthma biomarkers.

Main Results:

ORMDL3 has multifaceted roles in allergic asthma, linked to sphingolipid homeostasis.
A potential unifying paradigm for ORMDL3's pathological functions is proposed.
Sphingolipid metabolites show potential as biomarkers for allergic asthma.

Conclusions:

ORMDL3 is a critical factor in allergic asthma pathogenesis, primarily through its role in regulating sphingolipid homeostasis.
Further research into ORMDL3 and sphingolipid metabolism could reveal novel therapeutic targets and diagnostic tools for asthma.
Sphingolipid metabolites represent a promising area for developing biomarkers for allergic asthma.