Related Experiment Video
Updated: Jan 21, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
32.4K
Management of asthma COPD overlap.
Diego Jose Maselli1, Nicola Alexander Hanania2
1Division of Pulmonary Diseases & Critical Care Medicine, Department of Medicine, University of Texas Health at San Antonio, San Antonio, Texas.
Summary
Asthma COPD overlap (ACO) patients face higher risks. Initial treatment should combine long-acting bronchodilators with inhaled corticosteroids, with long-acting muscarinic antagonists as add-on therapy for better management.
Area of Science:
- Pulmonology
- Respiratory Medicine
- Clinical Therapeutics
Background:
- Asthma COPD overlap (ACO) is associated with increased patient morbidity compared to asthma or COPD alone.
- Limited evidence exists for optimal therapeutic strategies in ACO patients due to exclusion from major clinical trials.
- Current management guidelines are largely based on expert consensus and strategy documents.
Purpose of the Study:
- To review the latest literature on management approaches for patients with asthma COPD overlap (ACO).
- To synthesize current understanding of ACO patient treatment based on available studies and expert recommendations.
Main Methods:
- Literature search conducted across PubMed/Medline, ClinicalTrials.gov, and the Cochrane Register of Controlled Trials.
- Inclusion of studies focusing on the management of asthma, COPD, and ACO.
- Review of existing data to identify current therapeutic recommendations and gaps in knowledge.
Main Results:
- Patients with ACO exhibit greater morbidity than those with isolated asthma or COPD.
- Initial ACO therapy should include a long-acting bronchodilator with inhaled corticosteroids, avoiding long-acting beta-agonist monotherapy.
- Long-acting muscarinic antagonists are effective in both asthma and COPD and are recommended as add-on therapy for ACO.
Conclusions:
- Prospective studies evaluating ACO-specific therapies are scarce.
- Future research should focus on phenotyping and identifying treatable traits to optimize ACO management strategies.
- Personalized treatment approaches are essential for effectively managing patients with asthma COPD overlap.
Related Concept Videos
01:26COPD: Management Using Bronchodilators and Corticosteroids
748
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
748
01:20Asthma: Pathogenesis and Management
1.3K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.3K
01:30Asthma-IV: Diagnostic and Management
3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
01:30Asthma-IV: Nursing Management
3.7K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
3.7K
01:29Asthma-I: Introduction
3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
01:20COPD: Pathogenesis and Clinical Features
1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K