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Updated: Jan 21, 2026

Designed for Molecular Recycling: A Lignin-Derived Semi-aromatic Biobased Polymer
Published on: November 30, 2020
Catalytic recycling of NAD(P)H
Shunichi Fukuzumi1, Yong-Min Lee2, Wonwoo Nam3
1Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea; Faculty of Science and Engineering, Meijo University, Nagoya, Aichi 468-8502, Japan.
Abstract:
A large number of industrially relevant enzymes depend upon dihydronicotinamide adenine dinucleotide (NADH) and dihydronicotinamide adenine dinucleotide phosphate (NADPH) cofactors, which are too expensive to be added in stoichiometric amounts. Existing NAD(P)H-recycling systems suffer from low activity, or the generation of side products. This review focuses on NAD(P)H cofactor regeneration catalyzed by transition metal complexes such as rhodium, ruthenium and iridium complexes using cheap reducing agents such as hydrogen (H2) and ethanol, which have attracted increasing attention as sustainable energy carriers. The catalytic mechanisms for the regioselective reduction of NAD(P)+ are discussed with emphasis on identification of catalytically active intermediates such as transition metal hydride complexes. Applications of NAD(P)H-recycling systems to develop artificial photosynthesis are also discussed.
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