Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Rheumatic Heart Disease IV: Nursing Management

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...

Rheumatic Heart Disease III: Medical Management

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Distant recurrence from thymoma biopsy seeding: a case report.

Mediastinum (Hong Kong, China)·2026

Same author

Pulmonary veno-occlusive disease: atypical presentation with unexplained exertional dyspnoea and hypoxaemia.

BMJ case reports·2025

Same author

Radiology-Pathology Correlation in Coatomer Subunit Alpha Syndrome With Novel Findings of Pulmonary Lymphangiectasia.

Journal of thoracic imaging·2022

Same author

E-Cigarette or Vaping Product Use-Associated Lung Injury: A Review for Pathologists.

Archives of pathology & laboratory medicine·2020

Same author

Systemic sclerosis-associated interstitial lung disease.

The Lancet. Respiratory medicine·2020

Same author

Desquamative interstitial pneumonia in a non-smoker with neurofibromatosis type 1 (Von Recklinghausen syndrome).

BMJ case reports·2020

Search research articles

Related Experiment Video

Updated: Jan 21, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Pulmonary Pathology in Rheumatic Disease.

Andrea V Arrossi¹

¹Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Clinics in Chest Medicine

|August 5, 2019

Summary

Pulmonary manifestations in rheumatoid diseases show diverse histology, often mimicking other lung conditions. Understanding these varied patterns is crucial for accurate diagnosis and treatment of rheumatic lung disease.

Keywords:

Connective tissue disorders Histopathologic patterns of injury IgG4-related disease Interstitial lung disease Pathology Pulmonary hypertension Pulmonary vasculitis

More Related Videos

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

Related Experiment Videos

Last Updated: Jan 21, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

Area of Science:

Rheumatology
Pulmonary Medicine
Pathology

Background:

Rheumatoid diseases can affect the lungs, leading to a wide range of pulmonary issues.
The pathology of these lung manifestations is complex and shares features with other lung diseases.
All parts of the lung anatomy can be impacted, resulting in diverse morphologic changes.

Purpose of the Study:

To describe the diverse histopathologic patterns of pulmonary involvement in rheumatoid diseases.
To highlight the overlap in histologic features between rheumatic lung diseases and other pulmonary conditions.
To discuss specific entities like vasculitides and IgG4-related disease affecting the lung.

Main Methods:

Review of histopathologic findings in pulmonary manifestations of rheumatoid diseases.
Description of patterns including interstitial lung disease, airway disorders, pleural processes, and vascular changes.
Discussion of histopathology for key conditions such as lung vasculitides and IgG4-related disease.

Main Results:

Pulmonary involvement in rheumatoid diseases exhibits significant histologic heterogeneity.
Observed patterns include interstitial lung disease, airway disorders, pleural disease, and vascular abnormalities.
Histologic features often overlap with idiopathic lung diseases and conditions associated with other systemic diseases.

Conclusions:

The diverse and overlapping histopathology of rheumatoid lung disease necessitates careful evaluation.
Recognition of specific patterns aids in differentiating rheumatic lung disease from other pulmonary pathologies.
Understanding the histopathology is key for managing lung complications in patients with rheumatic diseases.