[Activation of phagocytosis by preparations of human alpha and gamma interferons]

Preparations of human alpha- and gamma-interferon differing by the method of production and purification had different capacity of activating phagocytosis of blood polymorphonuclear leukocytes from patients with dermatoses. Native preparations of alpha- and gamma-interferon had the highest phagocytosis-activating potency. A high level of this activity was also demonstrated with human leukocyte interferon II for injections purified by highly specific methods. A concentrated preparation of human leukocyte interferon for injections with a specific activity above 1 million IU/1 mg of protein and recombinant alpha 2-interferon (reaferon) exhibited minimal phagocytosis activating effect.