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Related Experiment Videos

Gallbladder non-Hodgkin's lymphoma: Case report.

Fei Gao1, Haichao Zhao2, Xidong Chen2

  • 1Shanxi Academy of Medical Sciences Shanxi Dayi Hospital, Longcheng Street 99, Taiyuan, Shanxi, 030032, China.

International Journal of Surgery Case Reports
|August 5, 2019
PubMed
Summary

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Extrahepatic biliary non-Hodgkin's lymphoma (EBNHL) is a rare cancer. This case highlights a misdiagnosed patient with EBNHL, hemophagocytic syndrome, and bile duct issues, leading to a fatal outcome.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Extrahepatic biliary non-Hodgkin's lymphoma (EBNHL) is exceptionally rare, comprising only 0.6% of malignant biliary tumors and 0.016% of all non-Hodgkin's lymphoma (NHL) cases.
  • Patients may present with symptoms mimicking common biliary conditions, such as bile duct disappearance syndrome and hemophagocytic syndrome.

Purpose of the Study:

  • To report a rare case of gallbladder non-Hodgkin's lymphoma.
  • To emphasize the diagnostic challenges and potential for misdiagnosis in rare biliary malignancies.
  • To highlight the importance of considering rare diagnoses in complex clinical presentations.

Main Methods:

  • A patient presented with intermittent fever and abdominal pain, initially treated for severe abdominal infection.
Keywords:
Bile duct disappearance syndromeCase reportExtrahepatic biliary non-Hodgkin’s lymphomaHematopoietic syndrome

Related Experiment Videos

  • Laparoscopic cholecystectomy was performed, but the patient's condition deteriorated postoperatively.
  • Postoperative pathological diagnosis confirmed gallbladder non-Hodgkin's lymphoma.

    • Main Results:

    • The patient's presentation included symptoms suggestive of severe infection, leading to initial misdiagnosis and inappropriate treatment.
    • Surgical intervention did not resolve the underlying condition, and the patient's health continued to decline.
    • The case was complicated by hemophagocytic syndrome and bile duct disappearance syndrome, further increasing diagnostic complexity.

    Conclusions:

    • Malignant lymphoma of the extrahepatic biliary system is extremely rare and often presents with non-specific symptoms, leading to diagnostic delays.
    • Non-calculus cholecystitis, especially when accompanied by fever, jaundice, and hepatosplenomegaly, warrants consideration of rare underlying malignancies.
    • This case underscores the critical need for thorough pathological examination in unexplained or refractory biliary conditions.