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Curing of 60Co gamma-resistance inducing effect of R46 R-factor by 5-fluorouracil
I Francia1, Z Hernádi, M Szabolcs
1Central Research Laboratory, László Hospital, Budapest, Hungary.
Acta Biochimica Et Biophysica Hungarica
|January 1, 1988
Abstract:
The 60Co gamma-resistance inducing effect of R46 factor, and its elimination by 5-fluorouracil were studied. R46 increased the survival of the wild-type strain and its rec- mutants. After treatment with 5-fluorouracil (1 g/liter) the clones lost not only antibiotic resistance, but the 60Co gamma-radioresistance as well, encoded by R46 R-factor.