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Updated: Jan 21, 2026
Diffusion Imaging in the Rat Cervical Spinal Cord
Published on: April 7, 2015
Value of diffusion-weighted and dynamic contrast-enhanced MR in predicting parametrial invasion in cervical stromal
Jiacheng Song1, Qiming Hu2, Zhanlong Ma1
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, 210029, China.
Objectives:
To compare the effectiveness of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) imaging in detecting parametrial invasion (PMI) in cervical stromal ring focally disrupted stage IB-IIA cervical cancers.
Methods:
Eighty-one patients with cervical stromal ring focally disrupted stage IB-IIA cervical cancers (PMI positive, n = 35; PMI negative, n = 46) who underwent preoperative MRI and radical hysterectomy were included in this study. Preoperative clinical variables and MRI variables were analyzed and compared.
Results:
The Ktrans (min, mean, 10%, 25%, 50%, 75%, 90%), Kep (min, 10%, 25%, 50%, 75%, 90%), and Ve (min, 10%, 25%, 50%, 75%, 90%) values of patients with PMI were significantly higher than patients without PMI. The apparent diffusion coefficient (ADC) value did not show statistical difference between the two groups (1.01 ± 0.21 vs. 0.97 ± 0.20 10-3 mm2/s, p = 0.360). Tumor craniocaudal planes were higher in PMI-positive group than PMI-negative group (35.84 ± 15.39 vs. 29.70 ± 11.78 mm, p = 0.048). Tumor craniocaudal planes combined with Kepmin value showed the highest area under the curve (AUCs) of 0.775, with a sensitivity of 72.7% and a specificity of 71.1% (p = 0.000).
Conclusions:
DCE parameters combined tumor craniocaudal planes may represent a prognostic indicator for PMI in cervical stromal ring focally disrupted IB-IIA cervical cancers.
Insights
Dynamic contrast-enhanced (DCE) imaging parameters, combined with tumor size, show promise in detecting parametrial invasion (PMI) in early-stage cervical cancer. This combination offers improved accuracy over diffusion-weighted imaging (DWI) alone.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Parametrial invasion (PMI) is a critical prognostic factor in cervical cancer.
- Accurate detection of PMI is essential for appropriate treatment planning and patient outcomes.
Purpose of the Study:
- To compare the effectiveness of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) imaging in detecting parametrial invasion (PMI).
- To evaluate the utility of specific MRI parameters in identifying PMI in stage IB-IIA cervical cancers.
Main Methods:
- Eighty-one patients with stage IB-IIA cervical cancer underwent preoperative MRI (DWI and DCE) and radical hysterectomy.
- Analysis included preoperative clinical and MRI variables, focusing on Ktrans, Kep, Ve, apparent diffusion coefficient (ADC) values, and tumor dimensions.
Main Results:
- DCE parameters (Ktrans, Kep, Ve) were significantly higher in patients with PMI.
- Tumor craniocaudal dimensions were larger in the PMI-positive group.
- The combination of tumor craniocaudal planes and Kepmin demonstrated the highest AUC (0.775) for detecting PMI.
Conclusions:
- DCE imaging parameters, particularly Kep, combined with tumor craniocaudal dimensions, may serve as a prognostic indicator for PMI.
- This combined approach shows potential for improved detection of parametrial invasion in cervical cancer.
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