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Related Experiment Video

Updated: Jan 21, 2026

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[Cost-effectiveness analysis of rabies immunization strategy based on dynamic-decision tree model].

D L Wang1, X F Zhang2, X C Wang2

  • 1Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China.

Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]
|August 6, 2019
PubMed
Summary

Increasing canine rabies vaccination coverage in China is cost-effective. A 70% dog vaccination rate is optimal, significantly reducing rabies transmission and improving public health outcomes.

Keywords:
Costs and cost analysisDynamic-decision treeImmune strategyRabies

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Area of Science:

  • Public Health
  • Epidemiology
  • Health Economics

Background:

  • Rabies remains a significant public health concern in China.
  • Current rabies prevention strategies require evaluation for cost-utility.

Purpose of the Study:

  • To assess the cost-utility of various canine rabies immunization strategies in China.
  • To identify the optimal rabies prevention approach for resource allocation.

Main Methods:

  • System dynamics modeling for canine rabies epidemic simulation.
  • Decision tree analysis for comparing immunization strategies.
  • Sensitivity analysis to identify key influencing factors.

Main Results:

  • A 70% canine vaccination coverage is the most cost-effective strategy from a societal perspective.
  • This strategy significantly outperforms the current approach (43% dog vaccination).
  • The probability of rabies virus in injured dogs is the most sensitive parameter influencing strategy choice.

Conclusions:

  • Increasing canine vaccination coverage is crucial for effective rabies prevention and control in China.
  • Higher vaccination rates offer substantial public health and economic benefits.