Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

61.8K
Overview
61.8K
Graded Potential01:19

Graded Potential

6.9K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
6.9K
Types of Aggregate Grading01:15

Types of Aggregate Grading

1.4K
Aggregate grading is crucial in economically obtaining a concrete mix with adequate strength, reasonable workability, and minimal segregation. There are four types of aggregate gradation: well-graded, uniformly (or one-sized) graded, gap-graded, and open-graded.
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
1.4K
Sieve Analysis and Grading Curves01:19

Sieve Analysis and Grading Curves

929
Sieve analysis is a method used to determine the particle size distribution of aggregate materials. This process involves the following steps:
929
Responses to Salt Stress02:02

Responses to Salt Stress

14.5K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.5K
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

14.7K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissecting bone marrow and plasma exosomal microRNA profiles following trauma.

Surgery·2026
Same author

Population Heterogeneity in Iron Biomarkers by Age, Sex, Menopausal Status, and Race in Healthy U.S. Adults: A Cross-Sectional Analysis from the All of Us Research Program.

Nutrients·2026
Same author

A murine model of sepsis induces age- and sex-specific chromatin remodeling in myeloid-derived suppressor cells.

Frontiers in immunology·2026
Same author

Divergent chromatin remodeling trajectories in CD66b <sup>+</sup> MDSCs distinguishes recovery from chronic critical illness after sepsis.

bioRxiv : the preprint server for biology·2026
Same author

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis.

bioRxiv : the preprint server for biology·2025
Same author

Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-Derived Suppressor Cells.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 21, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.0K

Chronic stress induces persistent low-grade inflammation.

Elizabeth S Miller1, Camille G Apple1, Kolenkode B Kannan1

  • 1University of Florida Health, Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, United States.

American Journal of Surgery
|August 6, 2019
PubMed
Summary
This summary is machine-generated.

Chronic stress in rats triggers persistent inflammation, indicated by increased cytokine levels and altered blood cell development. This finding is crucial for understanding stress-related health impacts.

Keywords:
C-reactive proteinIL-6InflammationNorepinephrineStress

More Related Videos

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

20.7K
A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

23.5K

Related Experiment Videos

Last Updated: Jan 21, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.0K
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

20.7K
A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

23.5K

Area of Science:

  • Immunology
  • Stress Physiology
  • Hematology

Background:

  • Chronic stress is a significant factor in health and disease.
  • Understanding the physiological mechanisms linking stress to inflammation is critical.

Purpose of the Study:

  • To investigate the systemic cytokine profile in rodents exposed to chronic restraint stress.
  • To determine if chronic stress induces persistent low-grade inflammation.

Main Methods:

  • Male Sprague-Dawley rats were subjected to restraint stress for 7 or 14 days.
  • Assessed plasma levels of norepinephrine (NE), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) using ELISA.
  • Quantified liver expression of IL-6 and TNF-α via real-time PCR.

Main Results:

  • Chronic stress (7 and 14 days) led to sequential increases in plasma NE, IL-6, TNF-α, and CRP.
  • Elevated liver IL-6 expression and increased hematopoietic progenitor cell mobilization were observed.
  • Erythroid progenitor colony growth was reduced, and weight gain was decreased in stressed rats.

Conclusions:

  • Chronic restraint stress induces a persistent inflammatory state in rodents.
  • This model provides a basis for studying inflammation's role in disease progression and outcomes when combined with trauma or sepsis models.