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Updated: Jan 21, 2026
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
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Cognitive Impairment in CKD: Pathophysiology, Management, and Prevention
David A Drew1, Daniel E Weiner1, Mark J Sarnak1
1Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA.
Summary
Patients with chronic kidney disease (CKD) face higher risks of cognitive impairment. Managing vascular risk factors and kidney function may slow decline, with transplantation showing cognitive benefits.
Area of Science:
- Nephrology
- Neurology
- Gerontology
Background:
- Chronic kidney disease (CKD) patients exhibit increased cognitive impairment risk.
- Lower glomerular filtration rate and albuminuria correlate with cognitive decline in CKD.
- Cerebrovascular disease is a primary driver, alongside uremic toxins, anemia, and polypharmacy.
Purpose of the Study:
- To review the relationship between CKD and cognitive impairment.
- To explore potential therapeutic strategies for cognitive decline in CKD patients.
- To highlight management approaches for co-occurring CKD and cognitive impairment.
Main Methods:
- Literature review of studies on CKD and cognitive function.
- Analysis of factors contributing to cognitive impairment in CKD.
- Evaluation of treatment outcomes for dialysis and kidney transplantation.
Main Results:
- Vascular risk factor modification may help, but data is limited.
- Blood pressure control and albuminuria reduction show modest benefits.
- Kidney transplantation improves cognitive function, unlike dialysis.
Conclusions:
- CKD significantly elevates cognitive impairment risk.
- Targeting vascular factors and kidney health is crucial.
- Comprehensive management and further research into novel therapies are needed.
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