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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Genome-wide Target Mapping Shows Histone Deacetylase Complex1 Regulates Cell Proliferation in Cucumber Fruit.

Zhen Zhang1, Bowen Wang2,3, Shenhao Wang1

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|August 6, 2019
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Cucumber's SF2 protein, a Histone Deacetylase Complex1 (HDC1) homolog, regulates fruit cell proliferation by controlling histone acetylation. This impacts phytohormone and cell cycle genes, revealing a key developmental mechanism.

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Area of Science:

  • Plant Biology
  • Molecular Genetics
  • Developmental Biology

Background:

  • Histone deacetylases (HDACs) regulate plant development via corepressor complexes.
  • Histone Deacetylase Complex1 (HDC1) is crucial for organ size, but its mechanism is unknown.

Purpose of the Study:

  • Investigate the role of HDC1 in cucumber fruit development.
  • Elucidate the molecular mechanism of HDC1-mediated regulation of cell proliferation.

Main Methods:

  • Identification and characterization of a cucumber short-fruit mutant (sf2).
  • Analysis of SF2 gene expression and protein function.
  • Genome-wide mapping of SF2 target genes.
  • Histone acetylation level assessment.

Main Results:

  • The sf2 mutant exhibits repressed cell proliferation.
  • SF2, an HDC1 homolog, is essential for normal fruit development.
  • Impaired SF2 function leads to elevated histone acetylation and affects chromatin targeting.
  • SF2 directly regulates genes involved in phytohormone pathways and cell cycle control.

Conclusions:

  • SF2 controls fruit cell proliferation by modulating histone acetylation of key developmental genes.
  • SF2 regulates cytokinin and polyamine biosynthesis and metabolism.
  • This study reveals a complex regulatory network for fruit cell proliferation mediated by HDC1.