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Experimental hantavirus infection in nonhuman primates
R Yanagihara1, H L Amyx, P W Lee
1Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland.
Archives of Virology
|January 1, 1988
Summary
Prospect Hill virus, a hantavirus, caused mild, temporary kidney issues in monkeys and a chimpanzee. This study demonstrates acute nephropathy in nonhuman primates from viruses linked to hemorrhagic fever with renal syndrome.
Area of Science:
- * Virology
- * Nephrology
- * Primate research
Background:
- * Hantaviruses are known to cause hemorrhagic fever with renal syndrome (HFRS) in humans.
- * The pathological mechanisms of hantavirus infections, particularly in nonhuman primates, require further elucidation.
- * Prospect Hill virus (PHV) is a hantavirus species identified in the United States.
Purpose of the Study:
- * To investigate the pathogenic effects of Prospect Hill virus in nonhuman primates.
- * To determine if PHV can induce acute nephropathy, a key feature of HFRS, in a primate model.
- * To establish a nonhuman primate model for studying hantavirus-induced renal disease.
Main Methods:
- * Intravenous inoculation of cynomolgus monkeys (Macaca fascicularis) and a chimpanzee (Pan troglodytes) with Prospect Hill virus.
- * Monitoring of clinical signs, including renal function markers.
- * Histopathological examination of renal tissues (not explicitly stated but implied by nephropathy).
Main Results:
- * Mild, transient proteinuria and azotemia were observed in inoculated nonhuman primates.
- * The observed renal abnormalities indicate an acute nephropathy.
- * These findings represent the first demonstration of acute nephropathy in nonhuman primates caused by viruses associated with HFRS.
Conclusions:
- * Prospect Hill virus can induce acute nephropathy in nonhuman primates.
- * Nonhuman primates serve as a relevant model for studying hantavirus-induced renal syndromes.
- * This study provides crucial insights into the pathogenesis of hantavirus infections and their renal manifestations.