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Related Experiment Video

Updated: Jan 21, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Optimization of cardiac resynchronization therapy based on speckle tracking.

D Sipula, M Kozak, J Sipula

    Bratislavske Lekarske Listy
    |August 6, 2019
    PubMed
    Summary

    Speckle tracking enhances Cardiac Resynchronization Therapy (CRT) optimization, particularly for dilated cardiomyopathy patients. Heart strain analysis, specifically A-strain, predicts improvement and guides therapy adjustments for better outcomes.

    Keywords:
    cardiac resynchronization therapyheart failureoptimizationspeckle tracking strain.

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    Area of Science:

    • Cardiology
    • Biomedical Engineering

    Background:

    • Cardiac Resynchronization Therapy (CRT) is vital for heart failure management.
    • Optimizing CRT parameters like AV and VV intervals is crucial for patient response.
    • Speckle tracking offers advanced imaging to assess cardiac mechanics.

    Purpose of the Study:

    • To correlate changes in heart strains with CRT optimization success.
    • To evaluate the utility of speckle tracking in guiding CRT optimization.
    • To compare optimization success rates in different etiologies of heart disease.

    Main Methods:

    • Prospective cohort study of 60 patients receiving CRT-Ds.
    • Initial CRT response evaluated after 3 months.
    • Speckle tracking used for AV and VV interval optimization in non-responders.
    • Optimization success reassessed after an additional 3 months.

    Main Results:

    • 39 patients showed a good initial response to CRT.
    • Subsequent optimization was more successful in dilated cardiomyopathy (DCM) than ischemic heart disease (IHD).
    • Ejection fraction increase and area strain were key predictors of improvement in NYHA class.

    Conclusions:

    • AV and VV optimization guided by speckle tracking shows promise, especially for DCM patients.
    • Speckle tracking, particularly A-strain analysis, can effectively guide CRT optimization.
    • This approach may improve CRT outcomes for non-responders.