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Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
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Hallmarks of senescence and aging
Slavica Dodig1, Ivana Čepelak1, Ivan Pavić2
1Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Biochemia Medica
|August 6, 2019
Summary
Biological aging results from genetics, environment, and time, involving inflammation and cellular senescence. Current biomarkers, like telomere length, lack accuracy for measuring biological age effectively.
Area of Science:
- Gerontology and cellular biology
- Investigating the biological mechanisms of aging
Background:
- Biological aging is influenced by genetics, environment, and time.
- Key aging factors include inflammation, immune system decline, and cellular senescence.
- Cellular senescence is a protective cell-cycle arrest triggered by stress or damage.
Purpose of the Study:
- To identify reliable biomarkers for objectively measuring biological age.
- To find indicators that reflect physiological aging independent of chronological age.
Main Methods:
- Review of existing literature on aging hallmarks and biomarkers.
- Evaluation of criteria for effective biological age biomarkers.
- Assessment of telomere length as a potential biomarker.
Main Results:
- Biological age can differ from chronological age.
- Reliable biomarkers are needed to accurately assess physiological aging.
- Telomere length shows poor predictive accuracy as a biomarker.
Conclusions:
- There is currently no single, reliable biomarker that meets all necessary criteria for measuring biological age.
- Further research is needed to discover and validate accurate biomarkers of aging.
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