Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Natural Selection?01:32

What is Natural Selection?

126.0K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
126.0K
The Resting Membrane Potential01:21

The Resting Membrane Potential

142.0K
Overview
142.0K
Subviral Agents01:29

Subviral Agents

542
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
542
Potential Energy00:52

Potential Energy

42.3K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.3K
Antibiotic Selection00:57

Antibiotic Selection

59.5K
Overview
59.5K
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.0K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HOTAIR at the metabolic crossroads: lncRNA control of carbohydrate and lipid metabolism.

Epigenomics·2026
Same author

Effect of peniocerol on human meniscal fibrochondrocyte inflammation induced by IL-1β and TNF-α through the NF-κB signaling pathway.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same author

The flavanol (-)-epicatechin induced different histological features and myogenic protein levels in triceps, gastrocnemius and plantaris of δ-sarcoglycan-deficient mice.

Tissue & cell·2026
Same author

Cellular plasticity and heterogeneity underlying therapy resistance in 3D cervical cancer models.

Hereditas·2026
Same author

miR-195 and miR-549a Are Essential Biomarkers for Early-Onset Colorectal Cancer.

International journal of molecular sciences·2026
Same author

Elucidating the Multicomponent Reaction Pathway of 2‑Pyrrolidone Synthesis.

ACS omega·2026

Related Experiment Video

Updated: Jan 21, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K

Selective Acetogenins and Their Potential as Anticancer Agents.

Nadia Jacobo-Herrera1, Carlos Pérez-Plasencia2,3, Víctor Alberto Castro-Torres4

  • 1Unidad de Bioquímica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Ciudad de México, Mexico.

Frontiers in Pharmacology
|August 6, 2019
PubMed
Summary
This summary is machine-generated.

Annonaceous acetogenins (AAs) from plants show significant antitumor potential. These compounds exhibit cytotoxicity and inhibit tumor growth, offering promising avenues for novel cancer drug discovery.

Keywords:
acetogeninsapoptosisautophagycell cyclecell deathcytotoxicity

More Related Videos

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung
07:10

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

Published on: May 20, 2019

14.4K
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.4K

Related Experiment Videos

Last Updated: Jan 21, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung
07:10

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

Published on: May 20, 2019

14.4K
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.4K

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Oncology

Background:

  • Plants, particularly the Kingdom Plantae, are a rich source of therapeutic compounds.
  • Annonaceous acetogenins (AAs), found in the Annonaceae family, are plant-derived secondary metabolites with traditional medicinal uses, including cancer treatment.

Purpose of the Study:

  • To review the role of annonaceous acetogenins (AAs) as antitumor agents.
  • To update readers on the significance of AAs in oncology drug discovery based on in vitro and in vivo studies.

Main Methods:

  • Literature search conducted in the PubMed scientific database.
  • Keywords included acetogenins, cancer, antitumor activity, cytotoxicity, and mechanism of action.

Main Results:

  • Annonaceous acetogenins (AAs) demonstrate cytotoxic effects, inducing apoptosis and cell cycle arrest in vitro.
  • AAs inhibit tumor growth in vivo and are linked to Complex I inhibition in tumor cell respiration.
  • The presence of mono or bis tetrahydrofuran rings with hydroxyl groups is associated with antineoplastic activity.

Conclusions:

  • Annonaceous acetogenins (AAs) are versatile compounds with significant potential as therapeutic agents for cancer treatment.
  • Further exploration of natural products like AAs is crucial for developing effective and less harmful cancer therapies.