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Measurement Variability Following MRI System Upgrade.

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  • 1Centre de Recherche CERVO, Quebec, QC, Canada.

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Siemens Magnetom Trio to Prisma^fit^ platform upgrades significantly altered MRI measurements. These changes in contrast-to-noise ratio, brain volume, and white matter hyperintensities impact longitudinal study analyses.

Keywords:
MRI upgradeSiemens healthcarelongitudinal studiesmagnetic resonance imagingmorphometryneuroimagingvariability

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Area of Science:

  • Medical Imaging
  • Neuroimaging
  • Radiology

Background:

  • Longitudinal studies frequently encounter MRI platform hardware/software changes.
  • Assessing the impact of these upgrades on imaging measurements is crucial for data integrity.

Purpose of the Study:

  • To evaluate variability in MRI measurements following Siemens Magnetom Trio upgrades to the Prisma^fit^ platform.
  • To determine the effects of these upgrades on image signal, brain morphometry, and white matter hyperintensities.

Main Methods:

  • Three healthy volunteers underwent MRI scans before and after three distinct platform upgrades.
  • Analyzed contrast-to-noise ratio (CNR) on T1-weighted (T1w) and fluid-attenuated inversion recovery (FLAIR) images.
  • Assessed brain morphometry on T1w and white matter hyperintensities (WMH) on FLAIR images.

Main Results:

  • Prisma^fit^ upgrades increased neocortical CNR by 30% and brain volume/thickness, particularly in frontal areas.
  • A correlation was found between neocortical CNR and neocortical volume.
  • FLAIR images showed no significant CNR change, but WMH volumes decreased by 68% post-upgrade.

Conclusions:

  • Siemens Prisma^fit^ upgrades significantly affect image signal, brain morphometry, and WMH measures.
  • These observed changes necessitate careful consideration in the analysis of longitudinal neuroimaging studies undergoing similar platform modifications.