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ADAMTS13: An Emerging Target in Stroke Therapy.

Xin Chen1, Xin Cheng2, Shufan Zhang1

  • 1Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.

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|August 6, 2019
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Summary

ADAMTS13, an enzyme that breaks down von Willebrand Factor, shows promise for treating acute ischemic stroke (AIS). It may serve as a biomarker and therapeutic agent for AIS, especially for thrombi resistant to tPA therapy.

Keywords:
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Area of Science:

  • Biochemistry
  • Vascular Biology
  • Neurology

Background:

  • Thrombosis underlies most acute ischemic strokes (AIS).
  • Current treatments like tPA have limitations and risks.
  • ADAMTS13 regulates von Willebrand Factor (VWF), crucial for thrombus formation.

Purpose of the Study:

  • To review the structure and function of ADAMTS13.
  • To explore the relationship between ADAMTS13 and AIS.
  • To evaluate ADAMTS13 as a potential biomarker and therapeutic agent for AIS.

Main Methods:

  • Literature review of in vitro, animal, and clinical studies.
  • Analysis of ADAMTS13's role in thrombosis, inflammation, and angiogenesis.
  • Focus on ADAMTS13's association with AIS occurrence, treatment, and prognosis.

Main Results:

  • ADAMTS13 dysfunction is linked to various diseases.
  • Recent findings connect ADAMTS13 to stroke.
  • ADAMTS13 influences AIS development, treatment response, and outcomes.

Conclusions:

  • ADAMTS13 is a potential biomarker for guiding AIS treatment.
  • ADAMTS13 shows promise as a therapeutic agent for tPA-resistant thrombi.