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The Hap Complex in Yeasts: Structure, Assembly Mode, and Gene Regulation.

Yinhe Mao1,2, Changbin Chen1

  • 1Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection and Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.

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|August 6, 2019
PubMed
Summary

The Hap complex, a crucial transcription factor in yeast, regulates respiration, reactive oxygen species, and iron homeostasis. This review details its structure, assembly, and regulatory roles in various yeast species.

Keywords:
CCAAT boxHap complexcytotoxicityiron homeostasisreactive oxygen speciesyeast

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Area of Science:

  • Molecular Biology
  • Yeast Genetics
  • Transcription Factor Regulation

Background:

  • CCAAT box-binding proteins are conserved eukaryotic heterotrimeric transcription factors.
  • The Hap complex, a fungal homolog, influences diverse cellular functions by separating DNA-binding and activation domains.
  • Existing literature comprehensively covers Hap complex in filamentous fungi but lacks a yeast-specific summary.

Purpose of the Study:

  • To review the structure and assembly of the Hap complex in representative yeast species.
  • To highlight recent advancements in understanding the regulatory functions of the yeast Hap complex.
  • To focus on the Hap complex's role in respiration, reactive oxygen species (ROS) production, and iron homeostasis.

Main Methods:

  • Literature review of studies on yeast Hap complex structure and assembly.
  • Analysis of recent research on Hap complex regulatory functions.
  • Synthesis of information on Hap complex involvement in respiration, ROS, and iron metabolism.

Main Results:

  • Detailed summary of Hap complex structure and assembly modes in various yeasts.
  • Elucidation of the Hap complex's significant role in regulating respiration.
  • Emphasis on the Hap complex's involvement in controlling reactive oxygen species (ROS) production and iron homeostasis.

Conclusions:

  • The Hap complex is a key regulator in yeast, impacting fundamental cellular processes.
  • Understanding yeast Hap complex structure and function is crucial for comprehending cellular regulation.
  • Further research into the Hap complex will advance our knowledge of yeast physiology and disease mechanisms.