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Updated: Jan 21, 2026

An Efficient Method to Obtain Dedifferentiated Fat Cells
Published on: July 15, 2016
Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass
Jeenal Gordhandas1, Grace Lin1, Ann M P Tipps1
1Department of Pathology, University of California San Diego, La Jolla, San Diego, CA, USA.
Abstract:
Dedifferentiated liposarcomas most commonly arise in the retroperitoneum, accounting for 10% of liposarcomas. Heterologous differentiation occurs in 5-10% of dedifferentiated liposarcomas; however, divergent osteosarcomatous differentiation is rare. We report a rare case of initial presentation of dedifferentiated liposarcoma with osteosarcomatous component as a colonic mass in a 72-year-old man. The tumor is mainly composed of bony trabeculae with intervening highly atypical cells and adjacent high-grade mesenchymal nonlipogenic tumor, as well as areas of well-differentiated liposarcoma. Immunohistochemical studies showed diffuse positivity for SATB2 in the atypical cells and fluorescence in situ hybridization revealed high-level amplification of MDM2 gene, supporting the diagnosis of well-differentiated and dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation.
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