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Related Experiment Video

Updated: Jan 21, 2026

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
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Gut Microbiota Changes in Patients with Bipolar Depression.

Shaohua Hu1,2,3, Ang Li4, Tingting Huang5

  • 1Department of Psychiatry First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 6, 2019
PubMed
Summary

This study reveals significant differences in gut microbiota between bipolar disorder (BD) patients and healthy individuals. Gut bacteria profiles can potentially aid in diagnosing BD and predicting treatment response.

Keywords:
16S rRNA gene sequencebiomarkersbipolar disordergut microbiotaquetiapine

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Area of Science:

  • Microbiome research
  • Neuropsychiatry
  • Pharmacogenomics

Background:

  • Bipolar disorder (BD) is a complex mental health condition.
  • The gut microbiome's role in neurological disorders is an emerging area of research.
  • Alterations in gut microbiota composition are increasingly linked to various health conditions.

Purpose of the Study:

  • To characterize the gut microbiota in bipolar disorder (BD) patients compared to healthy controls (HCs).
  • To investigate the impact of quetiapine treatment on the gut microbiota in BD patients.
  • To explore the potential of gut microbiota as a diagnostic and prognostic biomarker for BD.

Main Methods:

  • 16S ribosomal RNA (rRNA) gene sequencing was employed to analyze gut microbial composition.
  • Random forest models were utilized to identify microbial biomarkers.
  • Comparison of microbial profiles between BD patients (untreated and treated) and HCs.

Main Results:

  • Significant differences in gut microbial composition and diversity were observed between BD patients and HCs.
  • Predominant phyla differed, with Bacteroidetes in BD patients and Firmicutes in HCs.
  • Lower levels of butyrate-producing bacteria were found in untreated BD patients.
  • Quetiapine treatment induced changes in microbial composition.
  • A microbial signature achieved an AUC of 0.81 for distinguishing untreated BD patients from HCs.
  • A distinct microbial signature achieved an AUC of 0.93 for differentiating treatment responders from non-responders.

Conclusions:

  • Gut microbiota composition is significantly altered in bipolar disorder patients.
  • Quetiapine treatment influences the gut microbiome in BD.
  • Microbiota-based biomarkers show promise for BD diagnosis and predicting treatment outcomes, warranting further validation.