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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Eosinophilic cystitis caused by Candida glabrata: A case report

David T Duong1, Harris S Goodman2

  • 1Urology Associates, P.C., 2801 Charlotte Avenue, Nashville, TN, 37209, USA.

Urology Case Reports
|August 6, 2019
PubMed

Insights

Eosinophilic cystitis, a rare bladder disease, may be linked to Candida glabrata infection. Treatment with fluconazole resolved symptoms and reduced eosinophil presence in a unique case study.

Area of Science:

  • Urology
  • Medical Mycology
  • Pathology

Background:

  • Eosinophilic cystitis is a rare bladder condition with unknown etiology and no standard treatment.
  • It presents with symptoms like irritative voiding and hematuria.

Observation:

  • A 61-year-old male presented with irritative voiding symptoms and gross hematuria.
  • Cystoscopy revealed diffuse urothelial erythema and a bladder wall ulcer.
  • Bladder biopsy confirmed eosinophilic cystitis with ulceration.

Findings:

  • Urine culture identified Candida glabrata in the patient.
  • Treatment with oral fluconazole led to symptom resolution.
  • Follow-up bladder biopsy showed a complete absence of eosinophils.

Implications:

  • This case report suggests a potential link between Candida glabrata and eosinophilic cystitis.
  • It highlights the efficacy of fluconazole in treating this specific presentation.
  • Further research is warranted to explore the role of fungal infections in eosinophilic cystitis.

Keywords:
Bladder biopsyCandida glabrataEosinophilic cystitisFluconazole

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