Related Experiment Video
Updated: Jan 21, 2026
07:14
Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids
Published on: May 16, 2025
638
Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting
Unnati Garg1, Swati Chauhan1, Upendra Nagaich1
1Amity Institute of Pharmacy, Amity University, Sector-125, Noida, Uttar Pradesh-201303.
Advanced Pharmaceutical Bulletin
|August 6, 2019
Summary
Chitosan nanoparticles offer a biodegradable and safe platform for targeted drug delivery. This review details their synthesis and diverse applications in medicine, highlighting their potential in various treatment strategies.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Nanoparticles (NPs) are explored for targeted and controlled drug delivery.
- Chitosan NPs are advantageous due to biodegradability, biocompatibility, low toxicity, and ease of preparation.
- Chitosan, a natural biopolymer, is GRAS-approved and amenable to functionalization for targeted delivery.
Purpose of the Study:
- To review the formation of chitosan.
- To describe the synthesis of chitosan nanoparticles (NPs).
- To explore the diverse applications of chitosan NPs in drug delivery.
Main Methods:
- Ionic cross-linking
- Covalent cross-linking
- Reverse micellar method
- Precipitation
- Emulsion-droplet coalescence
Main Results:
- Chitosan NPs can be synthesized using various cross-linking and precipitation methods.
- These NPs demonstrate broad applicability across numerous drug delivery routes.
- Key applications span ocular, oral, pulmonary, nasal, mucosal, buccal, vaginal, and cancer therapies, as well as gene and vaccine delivery.
Conclusions:
- Chitosan NPs represent a versatile and effective system for advanced drug delivery.
- Their inherent properties facilitate targeted and controlled release of therapeutic agents.
- Further research into chitosan NP applications promises significant advancements in various medical fields.
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