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Epigenetic Reprogramming and Emerging Epigenetic Therapies in CML
Jane Bugler1, Ross Kinstrie1, Mary T Scott1
1Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
Frontiers in Cell and Developmental Biology
|August 6, 2019
Summary
Novel epigenetic therapies offer a promising strategy to cure chronic myeloid leukemia (CML). Targeting epigenetic alterations in CML may eradicate residual disease when combined with current treatments.
Area of Science:
- Hematology
- Oncology
- Epigenetics
Background:
- Chronic myeloid leukemia (CML) is a stem cell disorder driven by the BCR-ABL1 fusion gene.
- Tyrosine kinase inhibitors (TKIs) have improved CML management but rarely achieve a cure.
- Residual disease persists in most patients, necessitating novel therapeutic approaches.
Purpose of the Study:
- To review epigenetic alterations in CML development and progression.
- To discuss the potential of epigenetic therapies for CML cure.
- To explore combining epigenetic therapies with existing treatments.
Main Methods:
- Review of scientific literature on CML epigenetics.
- Examination of altered epigenetic mechanisms (histone modifications, DNA methylation).
- Discussion of therapeutic strategies targeting epigenetic processes.
Main Results:
- Epigenetic mechanisms are reprogrammed during CML progression.
- These alterations impact histone modifications, DNA methylation, and gene transcription.
- Epigenetic therapies show potential for eradicating residual CML disease.
Conclusions:
- Epigenetic alterations are key features of CML.
- Targeting these alterations offers a promising path toward CML cure.
- Combination therapy with TKIs and epigenetic agents may improve cure rates.
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