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Related Concept Videos

Migration00:53

Migration

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Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
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Cell Migration01:19

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Related Experiment Video

Updated: Jan 21, 2026

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments
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Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments

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Prenatal Environment That Affects Neuronal Migration.

Hye M Hwang1,2, Ray Y Ku1, Kazue Hashimoto-Torii1,3

  • 1Center for Neuroscience Research, Children's National Medical Center, The Children's Research Institute, Washington, DC, United States.

Frontiers in Cell and Developmental Biology
|August 6, 2019
PubMed
Summary
This summary is machine-generated.

Prenatal environmental stress disrupts crucial neuronal migration, leading to brain dysfunction like epilepsy. This review covers radial and tangential migration, and shared mechanisms in neuronal migration disorders (NMDs).

Keywords:
Cxcl12/Cxcr4 signalingfetal brain developmentheat shock signalingneuronal migrationneuronal migration disordersprenatal environmental stress

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Toxicology

Background:

  • Neuronal migration is vital for brain development, occurring from the prenatal period into infancy.
  • Disruptions in neuronal migration can lead to severe brain dysfunctions, including epilepsy.
  • Prenatal exposure to environmental stressors like alcohol, drugs, and inflammation are known to cause neuronal migration disorders (NMDs).

Purpose of the Study:

  • To review recent findings on neuronal migration disorders (NMDs).
  • To focus on radial and tangential migration during cortical development.
  • To discuss shared molecular mechanisms underlying NMDs caused by various prenatal environmental stresses.

Main Methods:

  • Literature review of recent scientific findings.
  • Comparative analysis of molecular changes in impaired neuronal migration.
  • Focus on radial and tangential neuronal migration modes.

Main Results:

  • Prenatal stress disrupts both radial and tangential neuronal migration.
  • Specific molecular changes are associated with impaired migration under different stress conditions.
  • Common mechanisms underlie NMDs irrespective of the specific prenatal stressor.

Conclusions:

  • Prenatal environmental stress significantly impacts neuronal migration, contributing to NMDs.
  • Understanding shared molecular pathways is key to addressing NMDs.
  • Further research into these mechanisms can inform therapeutic strategies for neurodevelopmental disorders.