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Updated: Jan 21, 2026
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Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics
Published on: November 30, 2012
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Pathomechanisms of Blood-Brain Barrier Disruption in ALS
Nicholas Kakaroubas1,2, Samuel Brennan1, Matthew Keon1
1Neurodegenerative Disease Section, Iggy Get Out, 19A Boundary Street, Darlinghurst NSW 2010, Sydney, Australia.
Neuroscience Journal
|August 6, 2019
Summary
The blood-brain barrier (BBB) becomes hyperpermeable in neurodegenerative diseases like ALS, potentially driving disease progression. This review explores BBB dysfunction and therapeutic strategies for these conditions.
Area of Science:
- Neuroscience
- Immunology
Background:
- The blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) regulate the central nervous system microenvironment.
- These barriers are crucial for neuronal function, nutrient supply, waste removal, and immune privilege.
Purpose of the Study:
- To review evidence suggesting BBB hyperpermeability as a disease-driving factor in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.
- To discuss factors influencing BBB permeability in these conditions.
Main Methods:
- Literature review of studies investigating BBB function in neurodegenerative diseases.
- Analysis of biochemical, physiological, and genomic factors affecting BBB permeability.
Main Results:
- Evidence indicates BBB hyperpermeability in ALS and related neurodegenerative conditions.
- BBB dysfunction allows detrimental molecules to enter the central nervous system, exacerbating disease.
Conclusions:
- BBB hyperpermeability is a significant contributor to ALS and neurodegenerative disease pathology.
- Targeting the BBB presents a promising therapeutic avenue for these debilitating diseases.
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