Related Experiment Video
Updated: Jan 21, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Synthesis of a Carbon Nanocone by Cascade Annulation
Kazutaka Shoyama1, Frank Würthner1,2
1Institut für Organische Chemie , Universität Würzburg , Am Hubland , 97074 Würzburg , Germany.
Abstract:
More than 50 years have passed since the first observation of graphitic cones in the pyrolysis of carbon. However, to date there has been no report in the literature on the synthesis of such carbon allotropes. Here we present the first synthesis of a carbon nanocone, which comprises a pentagon encircled by 30 hexagons, by means of a palladium-catalyzed cross-coupling reaction. In this synthetic approach, 15 C-C bonds were constructed from a cone-shaped aromatic scaffold, corannulene, and five naphthalene dicarboximide moieties through a cascade of [3 + 3] and [4 + 2] annulations. The conical geometry of the first synthetic carbon nanocone was confirmed by X-ray crystallography. The optical and electronic properties of this graphitic cone were elucidated by UV/vis and fluorescence spectroscopy and cyclic voltammetry.
More Related Videos
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
11:14Two-way Valorization of Blast Furnace Slag: Synthesis of Precipitated Calcium Carbonate and Zeolitic Heavy Metal Adsorbent
Published on: February 21, 2017
Related Concept Videos
Intracellular Signaling Cascades
Rab Cascades
Cascaded Op Amps
In a cascaded system, each op-amp is referred to as a stage. The output of one stage drives the input of the subsequent stage. As the input signal passes through...
MAPK Signaling Cascades
Amplifying Signals via Enzymatic Cascade
The Carbon Cycle