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Primary hemostatic function in dogs with acute kidney injury
Duana McBride1, Rosanne E Jepson1, Stefano Cortellini1
1Department of Clinical Science and Services, The Royal Veterinary College, University of London, London, United Kingdom.
Journal of Veterinary Internal Medicine
|August 6, 2019
Summary
Dogs with acute kidney injury (AKI) show impaired platelet function and a potential type II von Willebrand disease-like condition. This study characterized primary hemostatic function in dogs with AKI.
Area of Science:
- Veterinary Medicine
- Nephrology
- Hematology
Background:
- Uremia, a complication of kidney disease, is associated with bleeding tendencies.
- Primary hemostasis is crucial for preventing excessive bleeding.
Purpose of the Study:
- To investigate primary hemostatic function in dogs diagnosed with acute kidney injury (AKI).
- To compare hemostatic parameters between dogs with AKI and healthy controls.
Main Methods:
- A prospective study involved 10 dogs with severe AKI (International Renal Interest Society grade III or higher) and 10 healthy controls.
- Evaluated packed cell volume (PCV), platelet count, platelet aggregometry (Multiplate), and von Willebrand factor antigen to collagen binding activity ratio (vWF:Ag:vWF:CBA).
- Buccal mucosal bleeding time was assessed in AKI dogs.
Main Results:
- Dogs with AKI had significantly lower PCV and reduced collagen-activated platelet aggregation compared to controls.
- Platelet counts were significantly higher in AKI dogs.
- A significantly higher vWF:Ag:vWF:CBA ratio was observed in AKI dogs, correlating strongly with creatinine levels.
Conclusions:
- Dogs with AKI exhibit impaired collagen-activated platelet aggregation.
- The findings suggest a type II von Willebrand disease-like phenotype in dogs with AKI, indicated by elevated vWF:Ag:vWF:CBA.
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