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Published on: September 13, 2011
Overactivation of the sodium-calcium exchanger and transient receptor potential in anesthesia-induced malignant
Peng Zhao1, Xiu-Min Liu2, Qian-Chuang Sun1
1Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, Jilin, China.
Abstract:
Malignant hyperthermia is a pharmacogenetic disorder, which is an uncommon but frequently fatal intricacy of inhalation anesthesia in man. It causes a quick rise in body temperature to highly irreversible levels, which causes death in around three of four cases. The trigger anesthetics cause an anomalous, continued ascent in myoplasmic calcium levels. Possible mechanisms by which continuous release of sodium, calcium from skeletal muscle plasma membrane and sarcoplasmic reticulum stores respectively can produce the profound hyperthermia are discussed.
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