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Engineered stem cells targeting multiple cell surface receptors in tumors

Sanam L Kavari1,2, Khalid Shah1,2,3

  • 1Center for Stem Cell Therapeutics and Imaging (CSTI), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Stem Cells (Dayton, Ohio)
|August 6, 2019
PubMed

Insights

Engineered stem cells target multiple receptors on cancer cells and the tumor microenvironment. This review explores strategies, mechanisms, and potential of these advanced stem cell therapeutics for cancer treatment.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Therapeutics

Background:

  • Stem cells naturally target tumors, offering potential for cancer therapy.
  • Engineered stem cells can be designed to specifically target cancer cells.
  • Recent advancements involve engineering stem cells to target multiple receptors on tumor and microenvironment cells.

Purpose of the Study:

  • To review rationales and strategies for developing multi-receptor targeted stem cells for cancer therapy.
  • To discuss the mechanisms of action for these engineered stem cells.
  • To explore the potential and challenges of multi-receptor targeted stem cells as cancer therapeutics.

Main Methods:

  • Review of current literature on stem cell tropism and engineering for cancer targeting.
  • Analysis of strategies for targeting multiple receptors on tumor cells and the tumor microenvironment.
  • Discussion of stem cell mechanisms of action in preclinical and clinical settings.

Main Results:

  • Stem cells can be engineered to target diverse cell types within the tumor microenvironment.
  • Multi-receptor targeting enhances specificity and efficacy of stem cell-based cancer therapies.
  • Engineered stem cells demonstrate promise in preclinical cancer models.

Conclusions:

  • Multi-receptor targeted stem cells represent a promising strategy for advanced cancer therapeutics.
  • Further research is needed to overcome challenges and optimize clinical translation.
  • Stem cell engineering offers a versatile platform for developing novel cancer treatments.
Keywords:
adult stem cellscancercell deathcell surface receptorssignal transduction

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