Related Experiment Video
Updated: Jan 21, 2026
04:34
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
1.6K
The Effect of Time on Root Coverage Outcomes: A Network Meta-analysis
L Tavelli1, S Barootchi1, F Cairo2
1Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Journal of Dental Research
|August 6, 2019
Summary
Connective tissue grafts (CTG) offer stable root coverage long-term, unlike other methods like enamel matrix derivative (EMD). Baseline recession and tissue width predict long-term stability for gingival recession treatments.
Area of Science:
- Periodontology
- Regenerative Dentistry
- Evidence-Based Dentistry
Background:
- Root coverage stability is crucial but lacks comparative evidence.
- Limited direct comparisons and small sample sizes hinder understanding of long-term outcomes.
Purpose of the Study:
- To conduct a network meta-analysis (NMA) assessing time-dependent root coverage outcomes.
- To compare different surgical approaches for root coverage, considering temporal stability.
Main Methods:
- A literature search identified randomized clinical trials (RCTs) with at least two time points.
- A mixed-models network meta-analysis (NMA) estimated treatment slopes for recession depth (REC), keratinized tissue width (KTW), and clinical attachment level.
- Sixty RCTs involving 2,554 gingival recessions were analyzed.
Main Results:
- Connective tissue graft (CTG) and enamel matrix derivative (EMD) showed superior initial REC reduction versus flap advancement alone.
- Only CTG procedures maintained gingival margin stability over time.
- EMD, acellular dermal matrix, collagen matrix, and flap alone tended towards recession recurrence.
- Baseline REC and KTW predicted long-term stability; geographic center effects were noted.
Conclusions:
- Connective tissue graft (CTG) is the most effective for stable, long-term root coverage.
- Network meta-analysis effectively compares multiple treatments, incorporating the critical factor of time.
- Baseline measurements are key predictors for the stability of root coverage outcomes.
Keywords:
acellular dermal graft tissuegingival recessionsurgical flapstissue graftstooth rootwound healingMore Related Videos
Related Concept Videos
02:26Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
02:24Predicting Reaction Outcomes
10.3K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.3K
01:09Directing Effect of Substituents: meta-Directing Groups
5.8K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
5.8K
02:18Network Covalent Solids
16.1K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.1K
01:13Outcomes of Glycolysis
106.8K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
106.8K
01:05Noncompartmental Analysis: Mean Residence Time
589
According to statistical moment theory, mean residence time (MRT) is an important measure in pharmacokinetics. MRT can be defined as the expected mean of a probability density function distribution. It provides valuable insights into drug disposition in the body.
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
589