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Published on: May 27, 2011
Toxoplasmosis as an Early Complication of Allogeneic Hematopoietic Cell Transplantation
Christine Robin1, Mathieu Leclerc1, Cécile Angebault2
1Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, Department of Hematology and Cellular Therapy, Créteil, France; University Paris-Est Créteil (UPEC), Créteil, France.
Abstract:
Among 419 consecutive allogeneic hematopoietic cell transplant recipients, we observed 17 (4.0%) cases of toxoplasmosis at a median time of day 45 (range, 6 to 322) after transplant. Seven of these 17 cases occurred before day 30 after transplant. Because of the lack of PCR screening and trimethoprim-sulfamethoxazole prophylaxis before engraftment, the diagnosis of toxoplasmosis was late, and 5 of these 7 patients died. Analyzing these cases, early Toxoplasma blood PCR screening, starting from transplant, is crucial.
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