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Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Rheumatic Heart Disease IV: Nursing Management01:20

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AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Anatomy of the Heart01:27

Anatomy of the Heart

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The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
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Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes
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Stable Ischemic Heart Disease.

Daniel Katz1, Michael C Gavin1

  • 1Beth Israel Deaconess Medical Center, Boston, Massachusetts (D.K., M.C.G.).

Annals of Internal Medicine
|August 6, 2019
PubMed
Summary
This summary is machine-generated.

Stable ischemic heart disease (SIHD) is a major cause of death, characterized by an oxygen supply-demand imbalance in the heart muscle. Recent advancements include new medications to prevent heart attacks and heart failure.

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Area of Science:

  • Cardiology
  • Vascular Medicine
  • Pathophysiology

Background:

  • Stable ischemic heart disease (SIHD) is a significant global health concern and a primary cause of mortality.
  • The core pathology involves a mismatch between myocardial metabolic needs and oxygen delivery, typically due to coronary artery atherosclerosis.
  • Patient presentations of SIHD, classically angina, exhibit considerable variability.

Purpose of the Study:

  • To provide an updated overview of stable ischemic heart disease (SIHD).
  • To highlight recent therapeutic advancements since 2014.
  • To discuss the management of ischemic complications.

Main Methods:

  • Review of recent clinical trials and pharmacological developments in SIHD management.
  • Analysis of updated guidelines and treatment strategies.
  • Synthesis of current understanding of SIHD pathophysiology and clinical presentation.

Main Results:

  • Several new pharmaceutical agents have been approved for SIHD treatment.
  • These medications aim to mitigate ischemic events like myocardial infarction and heart failure.
  • The updated therapeutic landscape offers improved options for managing SIHD.

Conclusions:

  • Significant progress has been made in pharmacological interventions for SIHD since 2014.
  • New drugs offer enhanced strategies to reduce adverse ischemic outcomes.
  • Continued research and clinical application are crucial for optimizing SIHD patient care.