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Updated: Jan 21, 2026
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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
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Involvement of Platelets in Cancers.
Diane Mege1, Mathilde Aubert1, Romaric Lacroix1,2
1Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France.
Seminars in Thrombosis and Hemostasis
|August 6, 2019
Summary
Platelets significantly contribute to cancer progression, metastasis, and thrombosis. Targeting platelets with aspirin or P2Y12 inhibitors may reduce cancer incidence and improve survival.
Area of Science:
- Hematology
- Oncology
- Thrombosis
Background:
- Cancer-related venous thromboembolism (VTE) is a major cause of mortality in cancer patients.
- Elevated platelet counts are independent predictors of cancer-associated VTE.
- Platelets influence cancer progression and malignancies, while cancer affects platelet activity.
Purpose of the Study:
- To review current literature on the role of platelets in cancer.
- To explore experimental and population-based evidence.
- To identify platelets as a potential therapeutic target.
Main Methods:
- Literature review of experimental results and population-based studies.
- Analysis of platelet involvement in cancer progression, metastasis, and thrombosis.
- Examination of current anti-platelet therapies.
Main Results:
- Platelets promote cancer progression via proangiogenic and antiangiogenic factors and matrix metalloproteinases.
- Platelets are involved in cancer-associated thrombosis through tumor cell activation.
- Anti-platelet agents like aspirin and P2Y12 inhibitors show promise in reducing cancer incidence and improving survival.
Conclusions:
- Platelets are crucial in tumor growth, metastasis, and thrombosis.
- Targeting platelets offers a potential therapeutic strategy for cancer prevention and treatment.
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