Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Systemic and Pulmonary Circulation

Overview of Systemic and Pulmonary Circulation

The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...

Control Systems: Applications

Control Systems: Applications

Electrical engineering plays a pivotal role in our daily lives, with control systems at the heart of many applications, from home appliances to sophisticated space shuttles. Control systems manage and regulate the behavior of devices and processes, ensuring they function safely, correctly, and efficiently.
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Drug Excretion: Pulmonary and Glandular Routes

Drug Excretion: Pulmonary and Glandular Routes

Gaseous substances like general anesthetics are absorbed and excreted through the lungs via simple diffusion. This process depends on factors such as pulmonary blood flow, respiration rate, and the substance's solubility. Gaseous anesthetics like nitrous oxide with low blood solubility are excreted rapidly, while compounds like alcohol, with high blood and tissue solubility, are excreted slowly.
Drugs can also be excreted in breast milk, which is crucial for breastfeeding infants. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microbiome-Targeted Antibiotics Provide No Additional Microbiologic or Inflammatory Benefit during Cystic Fibrosis Pulmonary Exacerbations: Results from the CFMATTERS Trial.

American journal of respiratory and critical care medicine·2026

Same author

From the gut to the lung: microbiota-associated metabolites as regulators of respiratory immunometabolism.

Mucosal immunology·2026

Same author

Contributors to the heterogeneity of response to CFTR modulators.

The Lancet. Respiratory medicine·2026

Same author

Therapeutic potential of dihydronicotinamide riboside (NRH) on obesity and glucose intolerance in mice.

Nature communications·2026

Same author

Interkingdom signaling elicited by bacterial extracellular vesicles in human cystic fibrosis airway epithelium and neutrophils.

Frontiers in cellular and infection microbiology·2026

Same author

Retraction of "3D Protein-Based Bilayer Artificial Skin for the Guided Scarless Healing of Third-Degree Burn Wounds in Vivo".

Biomacromolecules·2026

Same journal

RETRACTED: Meligy et al. Therapeutic Potential of Mesenchymal Stem Cells Versus Omega n - 3 Polyunsaturated Fatty Acids on Gentamicin-Induced Cardiac Degeneration. <i>Pharmaceutics</i> 2022, <i>14</i>, 1322.

Pharmaceutics·2026

Same journal

Correction: Mohite et al. Bioactive Compound-Fortified Nanomedicine in the Modulation of Reactive Oxygen Species and Enhancement of the Wound Healing Process: A Review. <i>Pharmaceutics</i> 2025, <i>17</i>, 855.

Pharmaceutics·2026

Same journal

Metal Nanoparticle-Reinforced Hydrogels Applied in the Inhibition of Clinical Pathogens: Structural Features, Mechanisms, and Biomedical Prospects.

Pharmaceutics·2026

Same journal

Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Cipepofol Across Diverse Clinical Populations.

Pharmaceutics·2026

Same journal

Artificial Intelligence in Nanopharmaceutical Development: From Predictive Design to Clinical Translation.

Pharmaceutics·2026

Same journal

Textilinin-1, a Snake Venom-Derived Kunitz-Type Protease Inhibitor, Accelerates Wound Healing Through Anti-Inflammatory, Antibacterial, and Pro-Regenerative Activities.

Pharmaceutics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 21, 2026

Generation of Alginate Microspheres for Biomedical Applications

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications.

Marcus Hill¹, Matthew Twigg², Emer A Sheridan³

¹School of Pharmacy, Queen's University Belfast Queen's University Belfast, Belfast BT7 1NN, UK.

|August 7, 2019

Summary

This summary is machine-generated.

New alginate/chitosan particles effectively deliver tobramycin to combat Pseudomonas aeruginosa infections in cystic fibrosis lung mucus. Functionalization with SLPI reduces inflammation and improves particle interaction with mucus, enhancing potential in vivo efficacy.

Keywords:

antimicrobial biomedical applications drug delivery systems particles

More Related Videos

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

Related Experiment Videos

Last Updated: Jan 21, 2026

Generation of Alginate Microspheres for Biomedical Applications

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

Area of Science:

Biomaterials Science
Pharmaceutical Sciences
Infectious Diseases

Background:

Cystic fibrosis (CF) involves chronic Pseudomonas aeruginosa infection and thickened mucus, complicating antibiotic treatment.
Tobramycin is a key antibiotic for deteriorating CF patients with chronic P. aeruginosa infection, often administered with colistimethate sodium.
Developing effective drug delivery systems for the pulmonary environment in CF is crucial.

Purpose of the Study:

To develop and characterize alginate/chitosan particles for tobramycin delivery in cystic fibrosis lung mucus.
To evaluate tobramycin loading, release, and in vitro efficacy against P. aeruginosa.
To assess the impact of secretory leukocyte protease inhibitor (SLPI) functionalization on particle properties and inflammatory response.

Main Methods:

Alginate/chitosan particles were prepared via precipitation.
Tobramycin loading and release kinetics were measured.
In vitro inhibition of P. aeruginosa by tobramycin-loaded particles was assessed.
SLPI functionalization effects on neutrophil elastase inhibition and mucus interaction were evaluated.

Main Results:

Alginate/chitosan particles demonstrated successful tobramycin loading and release.
Released tobramycin exhibited in vitro inhibitory activity against P. aeruginosa.
SLPI-functionalized particles reduced neutrophil elastase activity, indicating anti-inflammatory potential.
Functionalization enhanced particle interaction with CF mucus, reducing penetration depth.

Conclusions:

Alginate/chitosan particles are a promising platform for tobramycin delivery in CF.
SLPI functionalization may improve the therapeutic potential of these particles by reducing inflammation and enhancing mucus interaction.
These findings suggest potential for improved in vivo efficacy in treating CF lung infections.