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Updated: Jan 21, 2026
11:31
Targeting Drugs to Larval Zebrafish Macrophages by Injecting Drug-Loaded Liposomes
Published on: February 18, 2020
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Formulation Strategies for Folate-Targeted Liposomes and Their Biomedical Applications
Parveen Kumar1, Peipei Huo1, Bo Liu2
1Laboratory of Functional Molecules and Materials, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Xincun West Road 266, Zibo 255000, China.
Pharmaceutics
|August 7, 2019
Summary
Folate-targeted liposomes utilize folate receptors on tumor cells for drug delivery. This review details the design and fabrication of these targeted liposomes for enhanced biomedical applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Oncology
Background:
- Folate receptor (FR) is a tumor-associated antigen.
- FR binds folic acid (FA) and its conjugates with high affinity.
- FR mediates endocytosis of bound molecules into FR-overexpressing cells.
Purpose of the Study:
- To provide detailed information on the design and fabrication of folate-conjugated liposomes.
- To review advances in folate-targeted liposomes.
- To discuss biomedical applications of folate-targeted liposomes.
Main Methods:
- Fabrication involves attaching FA to phospholipids, cholesterol, or peptides.
- Utilizes uncleavable/cleavable linkages for FA attachment.
- Liposomal formulation follows FA conjugation.
Main Results:
- Folate-conjugated liposomes demonstrate high efficacy as targeted delivery systems.
- A variety of payloads can be delivered to FR-overexpressing cells.
- Rational design requires interdisciplinary understanding of chemical and biomedical aspects.
Conclusions:
- Folate-targeted liposomes are effective for delivering payloads to cancer cells.
- Advances in design and fabrication enhance their biomedical utility.
- Further research in this interdisciplinary field is crucial for optimizing targeted therapies.
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