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Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis
Meghna Kataria1, Hiroyuki Yamano2
1UCL Cancer Institute, University College London, London WC1E 6DD, UK. m.kataria.12@ucl.ac.uk.
Cells
|August 7, 2019
Summary
Cell division relies on protein phosphatases and the anaphase-promoting complex/cyclosome (APC/C). This review details how these crucial regulators interact to ensure accurate mitosis and cell propagation.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Accurate cell division is essential for life propagation.
- Protein phosphorylation and degradation are key mechanisms controlling mitosis.
- Protein phosphatases and the anaphase-promoting complex/cyclosome (APC/C) are critical regulators of cell cycle progression.
Purpose of the Study:
- To review the intricate interplay between protein phosphatases and the APC/C.
- To highlight mechanisms ensuring accurate spatiotemporal control of mitosis.
- To present recent insights and conceptual advances in understanding this regulation.
Main Methods:
- Literature review of recent studies.
- Analysis of direct and indirect regulatory mechanisms.
- Focus on interregulation between phosphatases and APC/C.
Main Results:
- Phosphatases and APC/C exhibit complex mutual regulation.
- These enzymes coordinate to control mitotic entry and exit.
- Interplay ensures orderly progression through mitosis.
Conclusions:
- The coordinated action of phosphatases and APC/C is vital for accurate cell division.
- Understanding their interplay provides insights into safeguarding mitosis.
- This review consolidates current knowledge on their mutual influence.
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