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Updated: Jan 21, 2026

Generation and Culturing of High-Grade Serous Ovarian Cancer Patient-Derived Organoids
Published on: January 6, 2023
HOX Genes in High Grade Ovarian Cancer
Praveena Idaikkadar1, Richard Morgan2, Agnieszka Michael3
1Postgraduate Medical School, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7YS, UK.
Abstract:
HOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. High grade ovarian cancer is the most lethal gynaecological malignancy. Our understanding of the role of HOX genes in the oncogenesis of ovarian cancer is evolving, and here we review their dysregulated expression patterns, their function in cell survival and invasion, their potential uses as biomarkers, and ways in which HOX genes are being targeted with new and existing drugs.
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